Antigenic Cartography: Visualizing Viral Evolution for Influenza Vaccine Design

Mankind has been fighting influenza for thousands of years. The 1918 pandemic killed 50-100 million people. Today, influenza kills roughly half a million people each year. Because the virus evolves, it is necessary for vaccines to track its evolution closely in order to remain effective.

Antigenic Cartography is a new computational method that allows a unique visualization of viral evolution. First published in 2004, the technique is now used to aid the WHO in recommending the composition of human influenza vaccines. It is also being applied to the design of pandemic influenza vaccines and to the study of a variety of other infectious diseases.

The rise of Antigenic Cartography is a remarkable story of how recent immunological theory, mathematics, and computer science have combined with decades of virological and medical research and diligent data collection to produce an entirely new tool with immediate practical impact.

This talk will give you food for thought regarding influenza, and move on to explain what Antigenic Cartography is, how it works, and exactly how it is used to aid vaccine strain selection—all in layman’s terms, with no need for a biological or mathematical background.